2-(Trifluoromethyl)benzeneboronic acid → HCID 67233856, compound

HRID 1465945Notes

Reaction equation

HRID 1465945 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1B(O)O.[CH2:14]([O:16][C:17]([C:19]1[N:24]=[CH:23][C:22]2[CH:25]=[C:26](Br)[S:27][C:21]=2[C:20]=1[OH:29])=[O:18])[CH3:15]>>[CH2:14]([O:16][C:17]([C:19]1[N:24]=[CH:23][C:22]2[CH:25]=[C:26]([C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[C:2]([F:13])([F:12])[F:1])[S:27][C:21]=2[C:20]=1[OH:29])=[O:18])[CH3:15]

Participants

3

Reactant 2

HCID 27343872-(Trifluoromethyl)benzeneboronic acidHCID 67233406HCID 67233406, compound

Product 1

HCID 67233856HCID 67233856, compound

Procedure

The title compound was prepared from 2-(trifluoromethyl)phenyl boronic acid and 2-bromo-7-hydroxy-thieno[3,2-c]pyridine-6-carboxylic acid ethyl ester, example 21.d, under conditions analogous to experimental example 21.e; MS: (+) m/z 367.9 (M+1)

Sources & evidence

ORD record
ord-bcf6460b427542d5b9373a477650d262
Source dataset
uspto-grants-2015_04
Patent number
US09000006B2

Reaction notes

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