HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 71009683, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| Reactant | 4-Fluoro-4'-hydroxybiphenyl | HCID 345420 | — |
| Reactant | tert-Butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate | HCID 5237175 | — |
| Product | HCID 71009683 | HCID 71009683 | — |
Reaction Steps
The procedure is the same as for Example 1 (Stage 1.2) starting from 1.50 g (7.45 mmol) of tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate (commercial), 2.15 g (11.18 mmol) of 4′-fluorobiphenyl-4-ol, 2.93 g (11.18 mmol) of triphenylphosphine and 2.26 g (11.18 mmol) of diisopropyl azodicarboxylate. After purification by chromatography on a column of silica gel, elution being carried out with dichloromethane, 1.55 g of the expected product are obtained in the form of an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09000010B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-ee32a051b7ed4f6a84b6adcd75f7cbbb |
| Source note | uspto-grants-2015_04 |