Chloroacetyl chloride → HCID 131732673, compound

Participants

Reaction Steps

A solution of tert-Butyl (2-{[2-(3-bromo-4-cyanophenyl)ethyl]amino}ethyl)carbamate (30 mg, 0.081 mmol) and TEA (30 mg, 0.30 mmol) in DCM (1 mL) was added chloroacetyl chloride (10 mg, 0.089 mmol) to the mixture at 0° C. The mixture was stirred at RT for 0.5 hour. Then the residue was diluted with DCM (20 mL) washed with water (5 mL×2) dried over Na2SO4 and concentrated in vacuo to give the desired product. MS m/z: 444 [M+1]+.

Provenance & Evidence