Chloroacetyl chloride → HCID 131732674, compound

Participants

Reaction Steps

A mixture of tert-Butyl (2-{[(6-cyano-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]amino}ethyl)carbamate (110 mg, 0.334 mmol), chloroacetyl chloride (42 mg, 0.37 mmol) and TEA (135 mg, 1.34 mmol) in 20 mL DCM was stirred at RT for 12 hours. The mixture was diluted with 50 mL DCM and then washed with water and brine, dried over anhydrous Na2SO4 and concentrated. The residue was purified via prep-TLC (EtOAc/Petroleum Ether=1:1) to give the title compound. MS m/z: 406 [M+1]+.

Provenance & Evidence