反应详情

温度

-70 °C

A mixture of 6-(Prop-2-en-1-yl)pyridine-3-carbonitrile (4.8 g, 33 mmol) in 80 mL of DCM and 20 mL of MeOH was cooled to −70° C. Ozone was bubbled through the mixture until the mixture turned blue (about 20 minutes). The excess of ozone was removed by flush with N2 flow until the mixture turned colorless. 5 mL of Me2S was added to the mixture which was then warmed slowly to room temperature and stirred for 2 hours. The solvent was removed under vacuum below 30° C. to afford the title compound which was used without further purification.

1. customOzone was bubbled through the mixture until the mixture
2. custom(about 20 minutes)
3. customThe excess of ozone was removed
4. customby flush with N2 flow until the mixture
5. addition5 mL of Me2S was added to the mixture which
6. temperaturewas then warmed slowly to room temperature
7. customThe solvent was removed under vacuum below 30° C.