Hydrochloric Acid → HCID 117599514, compound

Participants

Reaction Steps

To a solution of Ethyl N-{2-[(tert-butoxycarbonyl)(6-cyano-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)amino]ethyl}glycinate (100 mg, 0.232 mmol) in dioxane was added HCl (1.16 ml, 4.6 mmol). The mixture was allowed to stir at RT until there was no SM left. The volatiles were removed, and the residue was dissolved in EtOH (15 ml). To this solution was added Hunig's Base (0.20 ml, 1.16 mmol). The solution was sealed in a microwave tube and heated to 155° C. for 5 hours. The product was then purified by MPLC. LC-MS (IE, m/z): 286 [M+1]+.

Provenance & Evidence