反应详情

6-Bromo-3,4-dihydro-1H-isochromen-1-one (3.0 g, 13 mmol) was dissolved in CCl4 (150 ml) then added N-bromosuccinimide (2.4 g, 13 mmol) followed by benzoyl peroxide (0.096 g, 0.40 mmol) and refluxed for 3 hours. Filtered and concentrated then chromatographed through a 120 g ISCO Redi-sep. column and eluted with 0-25% EtOAc/Hexane to yield the title compound. LC-MS (IE, m/z): 306.9 [M+1]+.

1. temperaturerefluxed for 3 hours
2. filtrationFiltered
3. concentrationconcentrated
4. customthen chromatographed through a 120 g ISCO Redi-sep
5. washcolumn and eluted with 0-25% EtOAc/Hexane