HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Oxo-5,6,7,8-tetrahydronaphthalene-2-carbonitrile → 6-{4-[2-(2,1,3-Benzoxadiazol-5-yl)ethyl]-3-oxopiperazin-1-yl}-5,6,7,8-tetrahydronaphthalene-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Oxo-5,6,7,8-tetrahydronaphthalene-2-carbonitrile | HCID 16244504 | — |
| Reactant | 1-[2-(2,1,3-Benzoxadiazol-5-yl)ethyl]-2-piperazinone | HCID 89526184 | — |
| Product | 6-{4-[2-(2,1,3-Benzoxadiazol-5-yl)ethyl]-3-oxopiperazin-1-yl}-5,6,7,8-tetrahydronaphthalene-2-carbonitrile | HCID 89533481 | — |
Reaction Steps
The title compound was prepared from 1-[2-(2,1,3-Benzoxadiazol-5-yl)ethyl]piperazin-2-one and 6-Oxo-5,6,7,8-tetrahydronaphthalene-2-carbonitrile following essentially the same procedure as Example 6. The product was purified by mass-directed reverse phase HPLC (AcCN-Water with 0.1% TFA). LC-MS (IE, m/z): 402 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08999990B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-12a6776c542243e28c200e2af592bf28 |
| Source note | uspto-grants-2015_04 |