Dimethylformamide → 6-{4-[2-(4-Cyanophenyl)ethyl]-2-oxopiperazin-1-yl}-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

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Reaction Conditions

Reaction Steps

To a flask charged with 6-(2-Oxopiperazin-1-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile (30 mg, 0.12 mmol) and a stir bar was added 1-(2-Bromoethyl)-4-nitrobenzene (39 mg, 0.19 mmol), K2CO3 (69 mg, 0.50 mmol), Tetrabutylammonium Iodide (12 mg, 0.025 mmol), and DMF (1 mL). The mixture was heated to 50° C. for 16 hours. LC showed product formation. The desired product was purified by mass-directed reverse phase HPLC (AcCN-Water with 0.1% TFA). LC-MS (IE, m/z): 385 [M+1]+.

Provenance & Evidence