反应详情

A solution of 5-[3-(Hydroxymethyl)oxiran-2-yl]-2-benzofuran-1(3H)-one (1.2 g, 5.8 mmol) in TEA.3HF (triethylamine trihydrofluoride) (10 mL) was warmed to 110° C. for 8 hours, and then cooled to RT. The reaction mixture was extracted with EtOAc (200 mL), washed with NaHCO3 (30 mL) and brine (30 mL). The organic layer was dried over Na2SO4, and then concentrated in vacuo. The residue was separated and purified with prep-TLC to give product the title product.

1. extractionThe reaction mixture was extracted with EtOAc (200 mL)
2. washwashed with NaHCO3 (30 mL) and brine (30 mL)
3. dry with materialThe organic layer was dried over Na2SO4
4. concentrationconcentrated in vacuo
5. customThe residue was separated
6. custompurified with prep-TLC