Hydrochloric Acid → HCID 46847168, compound

Participants

Reaction Steps

As described in example 1, a solution of [6,7-dimethoxy-4-(pyrrolidine-1-carbonyl)-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester (59 mg) was treated with HCl in EtOAc to give 42 mg (84%) of (1-aminomethyl-6,7-dimethoxy-isoquinolin-4-yl)-pyrrolidin-1-yl-methanone hydrochloride: 1H NMR (DMSO-d6) δ 1.74-1.81 (m, 2H), 1.86-1.92 (m, 2H), 3.10 (t, 2H, J=6.41 Hz), 3.59 (t, 2H, J=6.50 Hz), 3.89 (s, 3H), 3.99 (s, 3H), 4.71 (m, 2H), 7.09 (s, 1H), 7.49 (s, 1H), 8.36 (s, 1H), 8.68 (br s, 3H); MS: APCI (M+H) calc'd for C17H21N3O3 316.2; found 316.1.

Provenance & Evidence