Water → HCID 71539791, compound

Participants

Reaction Steps

Potassium carbonate (0.43 g, 3 mmol) was added to a mixture of 5-(((3,5-bis(trifluoromethyl)benzyl)amino)methyl)-1-(tert-butyl)-N,N-bis(cyclopropylmethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-amine (0.6 g, 1 mmol) and 5-bromo-2-chloropyrimidine (0.6 g, 3 mmol) in DMF. The resultant mixture was stirred at 100° C. for 12-16 h. The reaction mixture was treated with water and extracted with ethylacetate (100 ml). The organic layer was washed with brine and dried over Na2SO4, concentrated under reduced pressure to obtain the crude product. This product was further purified by column chromatography using silica gel (60-120 mesh) and 5% ethyl acetate in petroleum ether as eluent.

Provenance & Evidence