Potassium Carbonate → HCID 71539516, compound

Participants

Reaction Conditions

Reaction Steps

5-(((3,5-Bis(trifluoromethyl)benzyl)(5-bromopyrimidin-2-yl)amino)methyl)-1-(tert-butyl)-N,N-bis(cyclopropylmethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-amine (150 mg, 0.207 mmol) and isobutyramide (0.018 g, 0.207 mmol) were dissolved in 1,4-dioxane (5 ml) in a sealed tube to which 1,2-transdiaminocyclohexane (0.007 g, 0.062 mmol), and CuI (0.007 g, 0.078 mmol) were added. The reaction mixture was de-gassed for 15 min with argon. K2CO3 (0.057 g, 0.414 mmol) was added to the reaction mixture and it was further degassed with argon for 15 min. The reaction mixture was then stirred at 80° C. for 3 days. Thereafter the reaction mixture was diluted with DCM-MeOH (3:1) mixture (10 ml), filtered through celite. The filtrate was concentrated under reduced pressure; purified by column chromatography using 60-120 silica gel and 25% EtOAc in petroleum ether as the eluent to obtain the title compound.

Provenance & Evidence