Potassium Phosphate, Tribasic → HCID 86271598, compound

Participants

Reaction Conditions

Reaction Steps

5-(((3,5-bis(trifluoromethyl)benzyl)(5-bromopyridin-2-yl)amino)methyl)-1-(tert-butyl)-N,N-bis(cyclopropylmethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-amine (0.05 g, 0.069 mmol) as prepared above, cyclopropyl boronic acid (0.007 g, 0.083 mmol) were dissolved in toluene (10 ml). To this tricyclohexylphosphine (0.002 g, 0.0069 mmol), Pd(OAc)2 (0.0007 g, 0.0034 mmol), K3PO4 (0.051 g, 0.241 mmol) were added. The mixture was stirred at 100° C. for 16 hr. The reaction mixture was diluted with water, extracted with EtOAc. The combined organic layer was washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The crude product thus obtained, was purified by column chromatography using silica gel 60-120 mesh, 10% EtOAc in petroleum ether as the eluent to obtain the title compound.

Provenance & Evidence