Hydrogen Peroxide → HCID 71539628, compound

Participants

Reaction Conditions

Reaction Steps

2-(((6-(Bis(cyclopropylmethyl)amino)-1-(tert-butyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)(3,5-bis(trifluoromethyl)benzyl)amino)pyrimidine-5-carbonitrile obtained in Example 10, (0.000074 mmol, 0.050 g) in ethanol was treated with 1% solution of KOH (5 ml) and catalytic amount of hydrogen peroxide. The reaction mixture was heated at 40° C. for 30 min. The reaction mixture was then concentrated under reduced pressure, treated with water and extracted with EtOAc. The organic layer was dried over sodium sulfate, concentrated under reduced pressure, and purified by column chromatography using silica gel and 40% EtOAc in petroleum ether as eluent to obtain the title compound.

Provenance & Evidence