Potassium Carbonate → HCID 71539682, compound

Participants

Reaction Conditions

Reaction Steps

5-(((3,5-Bis(trifluoromethyl)benzyl)(5-bromopyrimidin-2-yl)amino)methyl)-1-(tert-butyl)-N,N-bis(cyclopropylmethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-amine (0.2 g, 0.293 mmol), obtained in step (vi) of Example 1,2-pyrrolidinone (0.024 g, 0.293 mmol), CuI (0.005 mg, 0.029 mmol), trans-1,2-diaminocyclohexane (0.007 g, 0.064 mmol) were taken in a sealed tube in 1,4-dioxane (5 mL), which was degassed with argon for 15 min. K2CO3 (0.08 g, 0.586 mmol) was added to it. The reaction mixture was stirred at 100° C. for 28 h. Thereafter the reaction mixture was filtered through celite, extracted with EtOAc. The combined organic layer was washed with water, dried over Na2SO4, concentrated under reduced pressure, and purified by column chromatography using EtOAc-petroleum ether as eluent to obtain the title compound.

Provenance & Evidence