反应详情

2,6-Dichloro-4-(2-methoxyethoxy)benzaldehyde (0.5 g, 2.0 mmol) in acetone (20 mL) were cooled down in ice bath and then potassium permanganate (0.47 g, 3.0 mmol) in water (5 mL) was added slowly under vigorous stirring. The reaction mixture was warmed up slowly to room temperature and reacted over 24 h. The reaction mixture was filtered through celite and washed with acetone. The organic phase was evaporated and then re-dissolved in EtOAc to be extracted with 1N HCl aqueous solution. The organic phase was dried over magnesium sulfate, filtered and concentrated in vacuum to afford the compound 2,6-dichloro-4-(2-methoxyethoxy)benzoic acid.

1. customreacted over 24 h
2. filtrationThe reaction mixture was filtered through celite
3. washwashed with acetone
4. customThe organic phase was evaporated
5. dissolutionre-dissolved in EtOAc
6. extractionto be extracted with 1N HCl aqueous solution
7. dry with materialThe organic phase was dried over magnesium sulfate
8. filtrationfiltered
9. concentrationconcentrated in vacuum