Acetone Cyanohydrin → 2-Methyl-2-(morpholin-4-yl)propanenitrile

HRID 1466351Notes

Reaction equation

HRID 1466351 reaction equation
[CH3:1][C:2]([CH3:6])(O)[C:3]#[N:4].[NH:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1>CC(C)=O>[CH3:1][C:2]([N:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1)([CH3:6])[C:3]#[N:4]

Participants

4

Reactant 2

HCID 6406Acetone CyanohydrinHCID 8083Morpholine

Product 1

HCID 24237842-Methyl-2-(morpholin-4-yl)propanenitrile

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Acetone cyanohydrin (4.3 g, 50 mmol) was dissolved into acetone (5 mL). Morpholine (4.3 g, 50 mmol) was added and the solution was stirred at rt for 24 h. The volatile solvents were removed in vacuo to give the title compound as a clear liquid in quantitative yield. MS ESI 155.0 [M+H]+, calcd for [C8H14N2O+H]+ 155.1.

Workup

  1. customThe volatile solvents were removed in vacuo

Sources & evidence

ORD record
ord-271458041dc241f49bb25bb31a42521c
Source dataset
uspto-grants-2015_04
Patent number
US08999968B2

Reaction notes

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