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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1466390Generated: November 4, 2026

3-(Trifluoromethyl)phenol → 3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazole-4-carboxylic acid

https://huagongshe.com/reaction/1466390

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethyl)phenolHCID 7376—
ReactantPotassium CarbonateHCID 11430—
Reactant5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehydeHCID 19754692—
Product3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazole-4-carboxylic acidHCID 66826025—

Reaction Steps

The title compound was prepared using 5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde and 3-trifluoromethylphenol in the manner similar to the method in Production Example 1 above except potassium carbonate was used instead of potassium hydroxide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09000024B2
Source datasetuspto-grants-2015_04
ORD IDord-9406c1acf5d9422ba65e4fb1d1a33b7e
Source noteuspto-grants-2015_04