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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1466404Generated: October 30, 2026

(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → 4-[(1S)-1-[[3-(Difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]pyrazole-4-carbonyl]amino]ethyl]benzoic acid

https://huagongshe.com/reaction/1466404

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(S)-Methyl 4-(1-aminoethyl)benzoate hydrochlorideHCID 57462942—
ReactantHCID 66826025HCID 66826025—
Product4-[(1S)-1-[[3-(Difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]pyrazole-4-carbonyl]amino]ethyl]benzoic acidHCID 56944705—

Reaction Steps

Example 21 was prepared using 3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazole-4-carboxylic acid and (S)-methyl 4-(1-aminoethyl)benzoate hydrochloride in a manner similar to the Example 4 above.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09000024B2
Source datasetuspto-grants-2015_04
ORD IDord-b0a487c37d9345218855b9f06b8f8da2
Source noteuspto-grants-2015_04