Water → HCID 131732692, compound

Participants

Reaction Steps

DDQ (160 mg, 0.71 mmol) was added to a solution of 1-2 (392 mg, 0.61 mmol) and H2O (0.9 mL) in CH2Cl2 (18 mL). After 30 minutes, saturated NaHCO3 solution (40 mL) was added and the resulting mixture was extracted with CH2Cl2 (3×25 mL). The combined CH2Cl2 solution was washed with brine and then was dried (Na2SO4), filtered and evaporated. The residue was purified by flash chromatography using a Combiflash unit from Teledyne Isco (0% ethyl acetate/hexanes→40%) to give the title compound (66 mg, 21%).

Provenance & Evidence