tert-Butyl 2-oxopiperidine-1-carboxylate → HCID 68470212, compound

HRID 1466513Notes

Reaction equation

HRID 1466513 reaction equation
[CH:1]1([NH:6][C:7]2[CH:8]=[C:9]([CH3:22])[CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:12]3)[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:23]([N:30]1CCCCC1=O)([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24]>>[C:23]([N:30]1[CH2:3][CH2:2][CH:1]([NH:6][C:7]2[CH:8]=[C:9]([CH3:22])[CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[CH:12]3)[CH2:5][CH2:4]1)([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24]

Participants

3

Reactant 2

HCID 7577838tert-Butyl 2-oxopiperidine-1-carboxylateHCID 25213243HCID 25213243, compound

Product 1

HCID 68470212HCID 68470212, compound

Procedure

7-Amino-5-methyl-2-phenyl-1H-indole prepared in Example 2 and 1-BOC-piperidinone were reacted according to the same procedure as Preparation 23 to give the title compound.

Workup

  1. customaccording to the same procedure as Preparation 23

Sources & evidence

ORD record
ord-209385e4841642079c7c228e5cce9b35
Source dataset
uspto-grants-2015_04
Patent number
US09000028B2

Reaction notes

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