Piperazin-2-one → HCID 68472953, compound

HRID 1466531Notes

Reaction equation

HRID 1466531 reaction equation
CO[C:3](=O)[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[NH:12][C:13]3[C:18]([CH:19]=2)=[CH:17][C:16]([Cl:20])=[CH:15][C:14]=3[NH:21][CH:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[CH:6]=1.[O:29]=[C:30]1[CH2:35][NH:34][CH2:33][CH2:32][NH:31]1>>[Cl:20][C:16]1[CH:17]=[C:18]2[C:13](=[C:14]([NH:21][CH:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)[CH:15]=1)[NH:12][C:11]([C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([CH2:4][CH2:3][N:34]3[CH2:33][CH2:32][NH:31][C:30](=[O:29])[CH2:35]3)[CH:6]=1)=[CH:19]2

Participants

3

Reactant 2

HCID 231360Piperazin-2-oneHCID 684777332-[3-(7-Tetrahydropyran-4-ylamino-5-chloro-1H-indol-2-yl)-phenyl]-acetic acid methyl ester

Product 1

HCID 68472953HCID 68472953, compound

Procedure

2-[3-(7-Tetrahydropyran-4-ylamino-5-chloro-1H-indol-2-yl)-phenyl]-acetic acid methyl ester prepared in Example 132 and 2-oxo-piperazine were reacted according to the same procedures as Example 32 and Steps A and B of Example 36 sequentially to give the title compound.

Sources & evidence

ORD record
ord-ddb7c006c6464447ac5f68bdf206ed34
Source dataset
uspto-grants-2015_04
Patent number
US09000028B2

Reaction notes

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