HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine → ethyl 5-(5-chloro-2-methoxyphenyl)-1H-pyrazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | Ethyl 2-(5-chloro-2-methoxybenzoyl)-3-(dimethylamino)acrylate | HCID 66847508 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | ethyl 5-(5-chloro-2-methoxyphenyl)-1H-pyrazole-4-carboxylate | HCID 66677632 | — |
Reaction Steps
A solution of ethyl 2-(5-chloro-2-methoxybenzoyl)-3-(dimethylamino)acrylate (2.49 g, 8.00 mmol, 1 eq) and hydrazine (0.40 mL, 13 mmol, 1.6 eq) in 20 mL ethanol was heated at 70° C. for 2 hours. Solvent and excess hydrazine were then evaporated to provide ethyl 5-(5-chloro-2-methoxyphenyl)-1H-pyrazole-4-carboxylate, which was used without further purification. LCMS (ESI) m+H=281.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08999998B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-45ea6379dec34a02966fbbd6fd6f092c |
| Source note | uspto-grants-2015_04 |