反应详情

温度

60 °C

To a solution of 2-hydroxyacetohydrazide (4.5 g, 50 mmol) in EtOH was added dropwise methyl isothiocyanate (3.7 g, 50 mmol) under ice cooling. After addition was complete the reaction mixture was brought to room temperature and then stirred for 24 hr at 60° C. Ice water was then added and stirring was continued for 15 min. The reaction mixture was concentrated in vacuuo to give the title compound. Yield: 100%. LCMS (ESI) m+H=164.0.

1. additionAfter addition
2. customwas brought to room temperature
3. stirringstirring
4. waitwas continued for 15 min
5. concentrationThe reaction mixture was concentrated in vacuuo