Methyl isothiocyanate → HCID 178486126, compound

HRID 1466650Notes

Reaction equation

HRID 1466650 reaction equation
[OH:1][CH2:2][C:3]([NH:5][NH2:6])=[O:4].[CH3:7][N:8]=[C:9]=[S:10]>CCO>[OH:1][CH2:2][C:3]([NH:5][NH:6][C:9]([SH:10])=[N:8][CH3:7])=[O:4]

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 3505362-Hydroxyacetohydrazide

Product 1

HCID 178486126HCID 178486126, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of 2-hydroxyacetohydrazide (4.5 g, 50 mmol) in EtOH was added dropwise methyl isothiocyanate (3.7 g, 50 mmol) under ice cooling. After addition was complete the reaction mixture was brought to room temperature and then stirred for 24 hr at 60° C. Ice water was then added and stirring was continued for 15 min. The reaction mixture was concentrated in vacuuo to give the title compound. Yield: 100%. LCMS (ESI) m+H=164.0.

Workup

  1. additionAfter addition
  2. customwas brought to room temperature
  3. stirringstirring
  4. waitwas continued for 15 min
  5. concentrationThe reaction mixture was concentrated in vacuuo

Sources & evidence

ORD record
ord-c53df2c0d7494bc688a32aa8bd4177c0
Source dataset
uspto-grants-2015_04
Patent number
US08999998B2

Reaction notes

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