Hydrochloric Acid → HCID 178481705, Verbindung

HRID 1466651Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1466651
[OH-].[Na+].[OH:3][CH2:4][C:5]([NH:7][NH:8][C:9]([SH:12])=[N:10][CH3:11])=O.Cl>CCO>[SH:12][C:9]1[N:10]([CH3:11])[C:5]([CH2:4][OH:3])=[N:7][N:8]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178486126HCID 178486126, Verbindung

Produkt 1

HCID 178481705HCID 178481705, VerbindungAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

5N NaOH (50 mmol) was added to a solution of 2-(2-hydroxyacetyl)-N-methylhydrazinecarbimidothioic acid (8.15 g, 50 mmol) in EtOH, and then the mixture was stirred for 4 hr at 60° C. The mixture was cooled in an ice bath and the pH was adjusted to ˜5-6 with concentrated HCl. The precipitated solid was filtered, washed with EtOH, and dried under vacuum to give the title compound. Yield: 83%. 1H NMR (DMSO-d6, 400 MHz) δ: 5.64 (s, 1H), 4.46 (s, 2H), 3.44 (s, 3H).

Aufarbeitung

  1. temperatureThe mixture was cooled in an ice bath
  2. filtrationThe precipitated solid was filtered
  3. washwashed with EtOH
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-4e2b8c1c92624dadaa2e33fd2a408752
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US08999998B2

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