HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1466755Generated: October 26, 2026
Hydrochloric Acid → [3-(2-Methyl-1H-indol-3-ylsulfanyl)-phenyl]-acetic acid
https://huagongshe.com/reaction/1466755
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Phenylhydrazine | HCID 7516 | — |
| Reactant | [3-(2-Oxo-propylsulfanyl)-phenyl]-acetic acid | HCID 66765032 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | [3-(2-Methyl-1H-indol-3-ylsulfanyl)-phenyl]-acetic acid | HCID 56840408 | — |
Reaction Steps
[3-(2-Oxo-propylsulfanyl)-phenyl]-acetic acid (0.200 g, 1.12 mmol) was dissolved in t-BuOH (5 mL) then phenylhydrazine (121 μL, 1.232 mmol) was added followed by HCl (1.232 mL, 1.0M in ether). The reaction was heated to 70° C. for 1 hour then cooled and submitted to aqueous workup to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09000025B2 |
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| Source dataset | uspto-grants-2015_04 |
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| ORD ID | ord-9c5fdd6e8d4947449349c1014b6df517 |
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| Source note | uspto-grants-2015_04 |
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