Ethyl Acetate → HCID 66765293, compound

Participants

Reaction Conditions

Reaction Steps

3-(6-Chloro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid methyl ester (0.050 g, 0.15 mmol) and 2-(bromomethyl)pyridine hydrobromide (0.049 g, 0.175 mmol) were dissolved in DMF:THF (1:1, 4 mL) and the mixture was cooled to 0° C. Cesium carbonate (0.122 g, 0.373 mmol) was added and the reaction was warmed to 90° C. for 30 minutes. The reaction as submitted to aqueous workup and silica gel chromatography (0-100% EtOAc in hexanes) to give the title compound.

Provenance & Evidence