Ethyl Acetate → 3-(3-Bromo-phenylsulfanyl)-6-chloro-2-methyl-1-pyridin-2-yl-1H-indole

Participants

Reaction Steps

3-(3-Bromo-phenylsulfanyl)-6-chloro-2-methyl-1H-indole (0.500 g, 1.4 mmol) along with K2CO3 (0.488 g, 3.5 mmol) and 2-fluoropyridine (87 μL, 2.1 mmol) were dissolved in DMF (2 mL) and reacted in a microwave at 200° C. for 20 minutes. The reaction was returned to the microwave at 200° C. for an additional 10 minutes. Standard workup followed by silica gel chromatography (0-100% EtOAc in hexanes) afforded the title compound.

Provenance & Evidence