1H-Pyrazole, 4-bromo-1-methyl- → {3-[6-Chloro-2-methyl-1-(1-methyl-1H-pyrazol-4-yl)-1H-indol-3-ylsulfanyl]-phenyl}-acetic acid ethyl ester

HRID 1466829Notes

Reaction equation

HRID 1466829 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12][C:13]2[C:21]3[C:16](=[CH:17][C:18]([Cl:22])=[CH:19][CH:20]=3)[NH:15][C:14]=2[CH3:23])[CH:7]=1)[CH3:2].Br[C:26]1[CH:27]=[N:28][N:29]([CH3:31])[CH:30]=1>>[CH2:1]([O:3][C:4](=[O:24])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12][C:13]2[C:21]3[C:16](=[CH:17][C:18]([Cl:22])=[CH:19][CH:20]=3)[N:15]([C:26]3[CH:27]=[N:28][N:29]([CH3:31])[CH:30]=3)[C:14]=2[CH3:23])[CH:7]=1)[CH3:2]

Participants

3

Reactant 2

HCID 1674331H-Pyrazole, 4-bromo-1-methyl-HCID 66765636[3-(6-Chloro-2-methyl-1H-indol-3-ylsulfanyl)-phenyl]-acetic acid ethyl ester

Product 1

HCID 66765084{3-[6-Chloro-2-methyl-1-(1-methyl-1H-pyrazol-4-yl)-1H-indol-3-ylsulfanyl]-phenyl}-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 42, Step 4, using the following starting materials: [3-(6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-phenyl]-acetic acid ethyl ester and 4-bromo-1-methylpyrazole.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-822475eb03734f269205b78dd64abaa0
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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