4-Bromo-1-propyl-1H-pyrazole → 3-[6-Chloro-2-methyl-1-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-ylsulfanyl]-benzoic acid ethyl ester

HRID 1466852Notes

Reaction equation

HRID 1466852 reaction equation
[CH2:1]([O:3][C:4](=[O:23])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[CH:16][C:17]([Cl:21])=[CH:18][CH:19]=3)[NH:14][C:13]=2[CH3:22])[CH:6]=1)[CH3:2].Br[C:25]1[CH:26]=[N:27][N:28]([CH2:30][CH2:31][CH3:32])[CH:29]=1>>[CH2:1]([O:3][C:4](=[O:23])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[CH:16][C:17]([Cl:21])=[CH:18][CH:19]=3)[N:14]([C:25]3[CH:26]=[N:27][N:28]([CH2:30][CH2:31][CH3:32])[CH:29]=3)[C:13]=2[CH3:22])[CH:6]=1)[CH3:2]

Participants

3

Reactant 2

HCID 218597074-Bromo-1-propyl-1H-pyrazoleHCID 667654983-(6-Chloro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid ethyl ester

Product 1

HCID 667653633-[6-Chloro-2-methyl-1-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-ylsulfanyl]-benzoic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 55, Step 2 using the following starting materials: 3-(6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid ethyl ester and 4-bromo-1-propylpyrazole.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-9d93fb2ba7ef486db19caef8d4696b2e
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

Loading…