1-benzyl-4-bromo-1H-pyrazole → 3-[1-(1-Benzyl-1H-pyrazol-4-yl)-6-chloro-2-methyl-1H-indol-3-ylsulfanyl]-benzoic acid ethyl ester

HRID 1466854Notes

Reaction equation

HRID 1466854 reaction equation
[CH2:1]([O:3][C:4](=[O:23])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[CH:16][C:17]([Cl:21])=[CH:18][CH:19]=3)[NH:14][C:13]=2[CH3:22])[CH:6]=1)[CH3:2].Br[C:25]1[CH:26]=[N:27][N:28]([CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:29]=1>>[CH2:1]([O:3][C:4](=[O:23])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[CH:16][C:17]([Cl:21])=[CH:18][CH:19]=3)[N:14]([C:25]3[CH:26]=[N:27][N:28]([CH2:30][C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)[CH:29]=3)[C:13]=2[CH3:22])[CH:6]=1)[CH3:2]

Participants

3

Reactant 2

HCID 29894661-benzyl-4-bromo-1H-pyrazoleHCID 667654983-(6-Chloro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid ethyl ester

Product 1

HCID 667653073-[1-(1-Benzyl-1H-pyrazol-4-yl)-6-chloro-2-methyl-1H-indol-3-ylsulfanyl]-benzoic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 55, Step 2 using the following starting materials: 3-(6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid ethyl ester and 4-bromo-1-benzylpyrazole.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-4565cfc6d5f34d1896a01993bdfa33d8
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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