1H-Pyrazole, 4-bromo-1-methyl- → 3-[6-Chloro-2-methyl-1-(1-methyl-1H-pyrazol-4-yl)-1H-indol-3-ylsulfanyl]-2-methoxy-benzoic acid ethyl ester

HRID 1466857Notes

Reaction equation

HRID 1466857 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[CH:16][C:17]([Cl:21])=[CH:18][CH:19]=3)[NH:14][C:13]=2[CH3:22])[C:6]=1[O:23][CH3:24])[CH3:2].Br[C:27]1[CH:28]=[N:29][N:30]([CH3:32])[CH:31]=1>>[CH2:1]([O:3][C:4](=[O:25])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[CH:16][C:17]([Cl:21])=[CH:18][CH:19]=3)[N:14]([C:27]3[CH:28]=[N:29][N:30]([CH3:32])[CH:31]=3)[C:13]=2[CH3:22])[C:6]=1[O:23][CH3:24])[CH3:2]

Participants

3

Reactant 2

HCID 1674331H-Pyrazole, 4-bromo-1-methyl-HCID 667648883-(6-Chloro-2-methyl-1H-indol-3-ylsulfanyl)-2-methoxy-benzoic acid ethyl ester

Product 1

HCID 667648283-[6-Chloro-2-methyl-1-(1-methyl-1H-pyrazol-4-yl)-1H-indol-3-ylsulfanyl]-2-methoxy-benzoic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 42, Step 4, using the following starting materials: 3-(6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-2-methoxy-benzoic acid ethyl ester and 4-bromo-1-methylpyrazole.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-bf27bfe247e1480fb9f3c7d6bbbfd0a5
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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