4-Bromo-1-ethyl-1H-pyrazole → 3-[1-(1-Ethyl-1H-pyrazol-4-yl)-6-methanesulfonyl-2-methyl-1H-indol-3-ylsulfanyl]-benzoic acid methyl ester

HRID 1466875Notes

Reaction equation

HRID 1466875 reaction equation
[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([S:10][C:11]2[C:19]3[C:14](=[CH:15][C:16]([S:20]([CH3:23])(=[O:22])=[O:21])=[CH:17][CH:18]=3)[NH:13][C:12]=2[CH3:24])[CH:5]=1.Br[C:27]1[CH:28]=[N:29][N:30]([CH2:32][CH3:33])[CH:31]=1>>[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([S:10][C:11]2[C:19]3[C:14](=[CH:15][C:16]([S:20]([CH3:23])(=[O:22])=[O:21])=[CH:17][CH:18]=3)[N:13]([C:27]3[CH:28]=[N:29][N:30]([CH2:32][CH3:33])[CH:31]=3)[C:12]=2[CH3:24])[CH:5]=1

Participants

3

Reactant 2

HCID 125652014-Bromo-1-ethyl-1H-pyrazoleHCID 667650383-(6-Methanesulfonyl-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid methyl ester

Product 1

HCID 667649673-[1-(1-Ethyl-1H-pyrazol-4-yl)-6-methanesulfonyl-2-methyl-1H-indol-3-ylsulfanyl]-benzoic acid methyl ester

Procedure

Prepared according to the procedure described in Example 55, Step 2 using the following starting materials: 3-(6-methanesulfonyl-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid methyl ester and 4-bromo-1-ethyl-1H-pyrazole.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d73a8dca076843e6b739718eeafc3a74
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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