Methyl iodide → [2-(6-Chloro-1,2-dimethyl-1H-indol-3-ylsulfanyl)-phenyl]-acetic acid

HRID 1466901Notes

Reaction equation

HRID 1466901 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([S:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH2:19][C:20]([OH:22])=[O:21])=[C:7]([CH3:11])[NH:8]2)=[CH:4][CH:3]=1.I[CH3:24]>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([S:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH2:19][C:20]([OH:22])=[O:21])=[C:7]([CH3:11])[N:8]2[CH3:24])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 56839997[2-(6-Chloro-2-methyl-1H-indol-3-ylsulfanyl)-phenyl]-acetic acid

Product 1

HCID 56840002[2-(6-Chloro-1,2-dimethyl-1H-indol-3-ylsulfanyl)-phenyl]-acetic acid

Procedure

Prepared according to the procedure described in Example 5, Step 2, using the following starting materials: [2-(6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-phenyl]-acetic acid and iodomethane.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-912dc88065d94714a8908de825d93c6b
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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