3-Chloro-4-fluorophenylhydrazine → 3-(6-Chloro-5-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid ethyl ester

HRID 1466921Notes

Reaction equation

HRID 1466921 reaction equation
[CH2:1]([O:3][C:4](=[O:16])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][CH2:12][C:13](=O)[CH3:14])[CH:6]=1)[CH3:2].[Cl:17][C:18]1[CH:19]=[C:20]([NH:25]N)[CH:21]=[CH:22][C:23]=1[F:24]>>[CH2:1]([O:3][C:4](=[O:16])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:21]3[C:20](=[CH:19][C:18]([Cl:17])=[C:23]([F:24])[CH:22]=3)[NH:25][C:13]=2[CH3:14])[CH:6]=1)[CH3:2]

Participants

3

Reactant 2

HCID 27365753-Chloro-4-fluorophenylhydrazineHCID 667651013-(2-Oxo-propylsulfanyl)-benzoic acid ethyl ester

Product 1

HCID 667654923-(6-Chloro-5-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 2, step 1, using the following starting materials: 3-(2-Oxo-propylsulfanyl)-benzoic acid ethyl ester and (3-Chloro-4-fluoro-phenyl)-hydrazine.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b884eab5ce414354bcd6e6436a2ec54d
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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