1H-Pyrazole, 1-(cyclopropylmethyl)-4-iodo- → HCID 66765118, compound

HRID 1466933Notes

Reaction equation

HRID 1466933 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[C:16]([F:22])[C:17]([Cl:21])=[CH:18][CH:19]=3)[NH:14][C:13]=2[CH3:23])[CH:6]=1)[CH3:2].[CH:25]1([CH2:28][N:29]2[CH:33]=[C:32](I)[CH:31]=[N:30]2)[CH2:27][CH2:26]1>>[CH2:1]([O:3][C:4](=[O:24])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[C:16]([F:22])[C:17]([Cl:21])=[CH:18][CH:19]=3)[N:14]([C:32]3[CH:31]=[N:30][N:29]([CH2:28][CH:25]4[CH2:27][CH2:26]4)[CH:33]=3)[C:13]=2[CH3:23])[CH:6]=1)[CH3:2]

Participants

3

Reactant 2

HCID 644309831H-Pyrazole, 1-(cyclopropylmethyl)-4-iodo-HCID 667655043-(6-Chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid ethyl ester

Product 1

HCID 66765118HCID 66765118, compound

Procedure

Prepared according to the procedure described in Example 55, Step 2 using the following starting materials: 3-(6-chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid ethyl ester and 1-cyclopropylmethyl-4-iodo-1H-pyrazole.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-474b3a47ef8c46e5bc1ac07dea11ded1
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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