4-iodo-1-propyl-1H-pyrazole → 3-[6-Chloro-7-fluoro-2-methyl-1-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-ylsulfanyl]-2-fluoro-benzoic acid ethyl ester

HRID 1466951Notes

Reaction equation

HRID 1466951 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[C:16]([F:22])[C:17]([Cl:21])=[CH:18][CH:19]=3)[NH:14][C:13]=2[CH3:23])[C:6]=1[F:24])[CH3:2].I[C:27]1[CH:28]=[N:29][N:30]([CH2:32][CH2:33][CH3:34])[CH:31]=1>>[CH2:1]([O:3][C:4](=[O:25])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[C:16]([F:22])[C:17]([Cl:21])=[CH:18][CH:19]=3)[N:14]([C:27]3[CH:28]=[N:29][N:30]([CH2:32][CH2:33][CH3:34])[CH:31]=3)[C:13]=2[CH3:23])[C:6]=1[F:24])[CH3:2]

Participants

3

Reactant 2

HCID 601366324-iodo-1-propyl-1H-pyrazoleHCID 667654293-(6-Chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-2-fluoro-benzoic acid ethyl ester

Product 1

HCID 667654493-[6-Chloro-7-fluoro-2-methyl-1-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-ylsulfanyl]-2-fluoro-benzoic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 55, Step 2 using the following starting materials: 3-(6-chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-2-fluoro-benzoic acid ethyl ester and 4-iodo-1-propyl-1H-pyrazole.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-6dfc2dc633e8465c829f4ec15cbc7d4a
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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