(3-Chloro-2-fluorophenyl)hydrazine hydrochloride → 3-(6-Chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-5-fluoro-benzoic acid ethyl ester

HRID 1466952Notes

Reaction equation

HRID 1466952 reaction equation
[CH2:1]([O:3][C:4](=[O:17])[C:5]1[CH:10]=[C:9]([S:11][CH2:12][C:13](=O)[CH3:14])[CH:8]=[C:7]([F:16])[CH:6]=1)[CH3:2].Cl.[Cl:19][C:20]1[C:21]([F:28])=[C:22]([NH:26]N)[CH:23]=[CH:24][CH:25]=1>>[CH2:1]([O:3][C:4](=[O:17])[C:5]1[CH:6]=[C:7]([F:16])[CH:8]=[C:9]([S:11][C:12]2[C:23]3[C:22](=[C:21]([F:28])[C:20]([Cl:19])=[CH:25][CH:24]=3)[NH:26][C:13]=2[CH3:14])[CH:10]=1)[CH3:2]

Participants

3

Reactant 2

HCID 25067375(3-Chloro-2-fluorophenyl)hydrazine hydrochlorideHCID 667649073-Fluoro-5-(2-oxo-propylsulfanyl)-benzoic acid ethyl ester

Product 1

HCID 667653183-(6-Chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-5-fluoro-benzoic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 2, Step 1, using the following starting materials: 3-fluoro-5-(2-oxo-propylsulfanyl)-benzoic acid ethyl ester and (3-chloro-2-fluoro-phenyl) hydrazine hydrochloride

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b82fd2a84b884eb5a6af0269c9b12bef
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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