4-Bromo-1-propyl-1H-pyrazole → 5-[6-Chloro-1-(1-propyl-1H-pyrazol-4-yl)-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl]-2-methoxy-benzoic acid ethyl ester

HRID 1466958Notes

Reaction equation

HRID 1466958 reaction equation
[CH2:1]([O:3][C:4](=[O:26])[C:5]1[CH:10]=[C:9]([S:11][C:12]2[C:20]3[C:15](=[C:16]([F:22])[C:17]([Cl:21])=[CH:18][CH:19]=3)[NH:14][C:13]=2[CH3:23])[CH:8]=[CH:7][C:6]=1[O:24][CH3:25])[CH3:2].Br[C:28]1[CH:29]=[N:30][N:31]([CH2:33][CH2:34][CH3:35])[CH:32]=1>>[CH2:1]([O:3][C:4](=[O:26])[C:5]1[CH:10]=[C:9]([S:11][C:12]2[C:20]3[C:15](=[C:16]([F:22])[C:17]([Cl:21])=[CH:18][CH:19]=3)[N:14]([C:28]3[CH:29]=[N:30][N:31]([CH2:33][CH2:34][CH3:35])[CH:32]=3)[C:13]=2[CH3:23])[CH:8]=[CH:7][C:6]=1[O:24][CH3:25])[CH3:2]

Participants

3

Reactant 2

HCID 218597074-Bromo-1-propyl-1H-pyrazoleHCID 667651205-(6-Chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-2-methoxy-benzoic acid ethyl ester

Product 1

HCID 667649635-[6-Chloro-1-(1-propyl-1H-pyrazol-4-yl)-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl]-2-methoxy-benzoic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 55, Step 2 using the following starting materials: 5-(6-Chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-2-methoxy-benzoic acid ethyl ester and 4-bromo-1-propyl-1H-pyrazole.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-45bda17ac03049dc94487b138caeb9ce
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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