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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1466983Generated: November 2, 2026

Diethyl (ethoxymethylene)malonate → Ethyl 7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

https://huagongshe.com/reaction/1466983

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl (ethoxymethylene)malonateHCID 6871—
Reactant3-FluoroanilineHCID 9742—
ProductEthyl 7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylateHCID 178469609—

Reaction Steps

Prepared as in Example 1c from 3-fluoroaniline and diethyl 2-(ethoxymethylene)malonate as a brown solid (51%). MS 236 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09000054B2
Source datasetuspto-grants-2015_04
ORD IDord-5915dca709674c7c957242c2ef5604df
Source noteuspto-grants-2015_04