L-Alaninol → HCID 66746006, compound

HRID 1467014Notes

Reaction equation

HRID 1467014 reaction equation
[NH2:1][C@@H:2]([CH3:5])[CH2:3][OH:4].[NH2:6][C:7]1[CH:14]=[CH:13][CH:12]=[C:11](F)[C:8]=1[C:9]#[N:10]>>[NH2:6][C:7]1[CH:14]=[CH:13][CH:12]=[C:11]([O:4][CH2:3][C@@H:2]([NH2:1])[CH3:5])[C:8]=1[C:9]#[N:10]

Participants

3

Reactant 2

HCID 80307L-AlaninolHCID 5226592-Amino-6-fluorobenzonitrile

Product 1

HCID 66746006HCID 66746006, compound

Procedure

Prepared as in Example 24d from (S)-2-aminopropan-1-ol and 2-amino-6-fluoro-benzonitrile as brown solid (73%). 1H NMR (400 MHz, DMSO-d6) δ 1.01 (d, J=6.5 Hz, 3H), 3.08 (m, 1H), 3.71 (d, J=6.1 Hz, 2H), 5.95 (s, 2H), 6.15 (d, J=8.3 Hz, 1H), 6.2 (d, J=8.3 Hz, 1H), 7.13 (t, J=8.3 Hz, 1H). MS 192 (MH+).

Sources & evidence

ORD record
ord-4e8082104e8d44ac9194e1a3c49cf977
Source dataset
uspto-grants-2015_04
Patent number
US09000054B2

Reaction notes

Loading…