Cycloheptanol → HCID 66747005, compound

HRID 1467023Notes

Reaction equation

HRID 1467023 reaction equation
[CH:1]1([OH:8])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:9][C:10]1[CH:17]=[CH:16][CH:15]=[C:14](F)[C:11]=1[C:12]#[N:13]>>[NH2:9][C:10]1[CH:17]=[CH:16][CH:15]=[C:14]([O:8][CH:1]2[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[C:11]=1[C:12]#[N:13]

Participants

3

Reactant 2

HCID 10399CycloheptanolHCID 5226592-Amino-6-fluorobenzonitrile

Product 1

HCID 66747005HCID 66747005, compound

Procedure

Prepared as in Example 22b from cycloheptanol and 2-amino-6-fluorobenzonitrile as yellow oil (11%). 1H NMR (400 MHz, DMSO-d6) δ 1.42-1.71 (m, 10H), 1.88-1.93 (m, 2H), 4.56 (m, 1H), 5.95 (s, 2H), 6.20 (d, J=8.0 Hz, 1H), 6.30 (d, J=8.0 Hz, 1H), 7.15 (t, J=8.0 Hz, 1H). MS 231 (MH+).

Sources & evidence

ORD record
ord-d2cd2f570261402eaf784f807ed276e1
Source dataset
uspto-grants-2015_04
Patent number
US09000054B2

Reaction notes

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