3-Phenoxy 1-propanol → HCID 66746008, compound

HRID 1467025Notes

Reaction equation

HRID 1467025 reaction equation
[O:1]([CH2:8][CH2:9][CH2:10][OH:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:12][C:13]1[CH:20]=[CH:19][CH:18]=[C:17](F)[C:14]=1[C:15]#[N:16]>>[NH2:12][C:13]1[CH:20]=[CH:19][CH:18]=[C:17]([O:11][CH2:10][CH2:9][CH2:8][O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:14]=1[C:15]#[N:16]

Participants

3

Reactant 2

HCID 803193-Phenoxy 1-propanolHCID 5226592-Amino-6-fluorobenzonitrile

Product 1

HCID 66746008HCID 66746008, compound

Procedure

Prepared as in Example 22b from 3-phenoxy-1-propanol and 2-amino-6-fluorobenzonitrile as a yellow oil (93%). 1H NMR (400 MHz, DMSO-d6) δ 2.14 (m, 2H), 4.10-4.16 (m, 4H), 5.98 (s, 2H), 6.23 (d, J=8.0 Hz, 1H), 6.33 (d, J=8.0 Hz, 1H), 6.89-6.94 (m, 5H), 7.16 (t, J=8.0 Hz, 1H).

Sources & evidence

ORD record
ord-354bd18bff2d449296e92f32c36cd861
Source dataset
uspto-grants-2015_04
Patent number
US09000054B2

Reaction notes

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