2-Amino-6-fluorobenzonitrile → HCID 66747165, compound

HRID 1467042Notes

Reaction equation

HRID 1467042 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[NH:8][C:9](=[O:13])[CH:10]([CH3:12])[CH3:11].[NH2:14][C:15]1[CH:22]=[CH:21][CH:20]=[C:19](F)[C:16]=1[C:17]#[N:18]>>[NH2:14][C:15]1[C:16]([C:17]#[N:18])=[C:19]([CH:20]=[CH:21][CH:22]=1)[O:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[NH:8][C:9](=[O:13])[CH:10]([CH3:11])[CH3:12]

Participants

3

Reactant 2

HCID 5226592-Amino-6-fluorobenzonitrileHCID 62367154HCID 62367154, compound

Product 1

HCID 66747165HCID 66747165, compound

Procedure

Prepared as in Example 22b from N-(2-hydroxycyclohexyl)isobutyramide (Example 39c) and 2-amino-6-fluorobenzonitrile as a brown solid (70%). MS 302 (MH+).

Sources & evidence

ORD record
ord-3314255880bd4b02b05be26c217b01f6
Source dataset
uspto-grants-2015_04
Patent number
US09000054B2

Reaction notes

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