Isobutyric Acid → N-(4-Hydroxycyclohexyl)isobutyramide

HRID 1467046Notes

Reaction equation

[C:1]([OH:6])(=O)[CH:2]([CH3:4])[CH3:3].[NH2:7][CH:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1>>[OH:14][CH:11]1[CH2:12][CH2:13][CH:8]([NH:7][C:1](=[O:6])[CH:2]([CH3:4])[CH3:3])[CH2:9][CH2:10]1

Participants

Reactant 2

HCID 6590Isobutyric Acid

HCID 812934-Aminocyclohexanol

Product 1

HCID 21533977N-(4-Hydroxycyclohexyl)isobutyramide

Procedure

Prepared as in Example 24a from isobutyric acid and 4-aminocyclohexanol as a colorless oil (44%). MS 186 (MH+).

Sources & evidence

ORD record: ord-50d09d2fd930414094044e206d1e485a
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09000054B2

Reaction notes

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