HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Hydroxyethoxy)-3-methoxybenzoic acid → (S)-ethyl 4-amino-5-(2-(4-(2-hydroxyethoxy)-3-methoxybenzamido)propoxy)-2-methylquinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Hydroxyethoxy)-3-methoxybenzoic acid | HCID 24694069 | — |
| Reactant | (S)-ethyl 4-amino-5-(2-aminopropoxy)-2-methylquinoline-3-carboxylate | HCID 86658188 | — |
| Product | (S)-ethyl 4-amino-5-(2-(4-(2-hydroxyethoxy)-3-methoxybenzamido)propoxy)-2-methylquinoline-3-carboxylate | HCID 86658194 | — |
Reaction Steps
Prepared as in Example 24a from (S)-ethyl 4-amino-5-(2-aminopropoxy)-2-methyl-quinoline-3-carboxylate (Example 26b) and 4-(2-hydroxyethoxy)-3-methoxybenzoic acid (Uto, Y. et al. Bioorg. Med. Chem. Lett. 2009, 19, 4151.) as a brown solid. MS 498 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09000054B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-9e9c9ba88599423a9679b06f78ade9cf |
| Source note | uspto-grants-2015_04 |