2-Amino-6-fluorobenzonitrile → HCID 66746609, compound

HRID 1467080Notes

Reaction equation

HRID 1467080 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C@H:2]1[CH2:6][OH:7].[NH2:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13](F)[C:10]=1[C:11]#[N:12]>>[NH2:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([O:7][CH2:6][C@@H:2]2[CH2:3][CH2:4][CH2:5][NH:1]2)[C:10]=1[C:11]#[N:12]

Participants

3

Reactant 2

HCID 5226592-Amino-6-fluorobenzonitrileHCID 640091L-Prolinol

Product 1

HCID 66746609HCID 66746609, compound

Procedure

Prepared as in Example 24d from (S)-pyrrolidin-2-ylmethanol and 2-amino-6-fluoro-benzonitrile as brown solid (51%). MS 218 (MH+).

Sources & evidence

ORD record
ord-a870016e6eab411fa2f8f3781cdf3f5b
Source dataset
uspto-grants-2015_04
Patent number
US09000054B2

Reaction notes

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