Acetic Anhydride → HCID 86658212, compound

HRID 1467087Notes

Reaction equation

[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:12][CH2:13][C@H:14]2[CH2:18][CH2:17][CH2:16][NH:15]2)[N:5]=[C:4]([CH3:19])[C:3]=1[C:20]([O:22][CH2:23][CH3:24])=[O:21].[C:25](OC(=O)C)(=[O:27])[CH3:26]>>[C:25]([N:15]1[CH2:16][CH2:17][CH2:18][C@@H:14]1[CH2:13][O:12][C:10]1[CH:9]=[CH:8][CH:7]=[C:6]2[C:11]=1[C:2]([NH2:1])=[C:3]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:4]([CH3:19])=[N:5]2)(=[O:27])[CH3:26]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 86658209HCID 86658209, compound

Product 1

HCID 86658212HCID 86658212, compound

Procedure

Prepared as in Example 24a from (R)-ethyl 4-amino-2-methyl-5-(pyrrolidin-2-ylmethoxy)quinoline-3-carboxylate (Example 92b) and acetic anhydride as brown solid (28%). MS 372 (MH+).

Sources & evidence

ORD record: ord-71d0c52e307a4394810d19a4bb672fd6
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09000054B2

Reaction notes

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