HRID1467101

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10561191

未命名化合物

结构：CCOC(=O)c1c(C)nc2cccc(OC[C@@H](N)C(C)C)c2c1N

HCID86658214

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1c(C)nc2cccc(OC[C@@H](NC(=O)c3ccc(OCCCO)c(OC)c3)C(C)C)c2c1N

HCID86658226

未命名化合物

PROCEDURE

实验过程

Prepared as in Example 24a from (S)-ethyl 4-amino-5-(2-amino-3-methylbutoxy)-2-methylquinoline-3-carboxylate (Example 95b) and 4-(3-hydroxypropoxy)-3-methoxybenzoic acid (Baraldi, P. G. et al. J. Med. Chem. 1999, 42, 5131.) as brown solid (29%). MS 540 (MH+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-30e783283d444000a0d375d58535e221
来源数据集: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09000054B2
来源说明: uspto-grants-2015_04

反应 SMILES

[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:12][CH2:13][C@@H:14]([NH2:18])[CH:15]([CH3:17])[CH3:16])[N:5]=[C:4]([CH3:19])[C:3]=1[C:20]([O:22][CH2:23][CH3:24])=[O:21].[OH:25][CH2:26][CH2:27][CH2:28][O:29][C:30]1[CH:38]=[CH:37][C:33]([C:34](O)=[O:35])=[CH:32][C:31]=1[O:39][CH3:40]>>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:12][CH2:13][C@@H:14]([NH:18][C:34](=[O:35])[C:33]2[CH:37]=[CH:38][C:30]([O:29][CH2:28][CH2:27][CH2:26][OH:25])=[C:31]([O:39][CH3:40])[CH:32]=2)[CH:15]([CH3:17])[CH3:16])[N:5]=[C:4]([CH3:19])[C:3]=1[C:20]([O:22][CH2:23][CH3:24])=[O:21]